Hypoxic stress granules trigger immunogenic dormancy in lung cancer
Matthew G. Smith, Alexis Rebecca Ramos, Heena Panchal, N Harun Cerkezi, Cassandra Garcia, Lynn A. Spruce, Hossein Fazalinia, Leonard B. Maggi, Adam William Mailloux
This study shows hypoxia blocks C1APP pathway components in lung cancer cells, leading to reduced immunopeptide presentation and immunogenic dormancy via stress granules.
bioRxiv · Feb 20, 2026 · PreprintCancer Biology