Lynn A. Spruce

The paper compares small and large extracellular vesicles from healthy pregnancies to identify subtype-specific cargo differences and establish a reference for normal EV biology.

This study identifies a gut-derived serine protease that reduces sleep but extends lifespan in Drosophila by increasing peripheral ROS, suggesting a link between sleep reduction and stress adaptation.

This study combines Tat-Beclin1 and endurance training in old male mice, showing improved physical function compared to either treatment alone.

This study uses μMap photo-proximity labeling to compare the interactomes of α-synuclein monomers and fibrils in mouse brain lysate to investigate synucleinopathy mechanisms.

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

This study shows hypoxia blocks C1APP pathway components in lung cancer cells, leading to reduced immunopeptide presentation and immunogenic dormancy via stress granules.

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.