Pharmacological inhibition of astrocytic transglutaminase 2 facilitates the expression of a neurosupportive astrocyte reactive phenotype in association with increased histone acetylation
Thomas Delgado, Jacen Emerson, Matthew Hong, Jeffrey W. Keillor, Gail V.W. Johnson
This study shows that inhibiting astrocytic TG2 with VA4 promotes a neurosupportive reactive phenotype through increased histone acetylation and altered transcriptional regulation.
bioRxiv · Apr 15, 2024 · PreprintNeuroscience