Gail V.W. Johnson

This study shows that deleting transglutaminase 2 improves metabolic support from astrocytes and reduces pathology after repetitive mild traumatic brain injury.

This paper uses computational techniques to analyze transcriptomic data and identify common pathways involving BAG family proteins in Alzheimer's and Parkinson's disease.

This study shows BAG3 depletion in astrocytes impairs clathrin-mediated endocytosis and reduces tau uptake, suggesting a role in Alzheimer's disease pathogenesis.

This study identifies FAM84B as a novel protein facilitating tau propagation through RYR3-mediated exocytosis in response to neuroinflammation.

This study shows that clearing tau proteins in C. elegans reverses neuronal dysfunction in both young and aged worms, suggesting potential for AD therapies targeting soluble tau.

The paper shows that phosphomimetic tau mutants inhibit mitophagy by reducing FKBP8 levels during oxidative stress in neuronal cells.

This study shows that inhibiting astrocytic TG2 with VA4 promotes a neurosupportive reactive phenotype through increased histone acetylation and altered transcriptional regulation.

This study shows BAG3 regulates how NBR1 and SQSTM1 recognize different MAPT species, impacting MAPT proteostasis in neurons and Alzheimer's disease.

This study shows that specific phosphorylation sites on tau affect mitochondrial function and stress responses in neuronal cells.

This study shows that inhibiting astrocytic TG2 with VA4 promotes a neurosupportive reactive phenotype through increased histone acetylation and altered transcriptional regulation.

The paper maps ROS dynamics in mitochondrial microdomains using all-optical methods to study spatiotemporal H2O2 diffusion and its effects on mitochondrial behavior.

This study identifies a BAG3-TBC1D10B-Rab35 regulatory axis that modulates ESCRT-dependent tau clearance and links its dysfunction to Alzheimer's disease pathogenesis.

This study shows that deleting or inhibiting astrocytic TG2 improves functional recovery after spinal cord injury by altering metabolic pathways and reducing reactive astrocyte markers.

This paper develops a C. elegans model to study how specific tau modifications contribute to neurodegeneration and mitophagy in Alzheimer's disease.

This study shows BAG3 and SYNPO promote autophagy-mediated degradation of phosphorylated MAPT in neuronal synapses, preventing its accumulation and maintaining synaptic health.