Jeffrey W. Keillor

This paper discovers and optimizes a CNS-penetrant covalent inhibitor of PIKfyve, DUN058, showing sustained target occupancy and modulation of protein clearance pathways in vivo.

This study shows TGM2 is involved in efferocytosis by glioblastoma-associated macrophages, promoting immunosuppression and tumor survival.

This study shows that inhibiting astrocytic TG2 with VA4 promotes a neurosupportive reactive phenotype through increased histone acetylation and altered transcriptional regulation.

This study shows that inhibiting astrocytic TG2 with VA4 promotes a neurosupportive reactive phenotype through increased histone acetylation and altered transcriptional regulation.

This study shows that deleting or inhibiting astrocytic TG2 improves functional recovery after spinal cord injury by altering metabolic pathways and reducing reactive astrocyte markers.