BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAE
Anup Dey, Matthew J Butcher, Anne Gégonne, Dinah S. Singer, Jinfang Zhu, Keiko Ozato
This study shows that microglia-specific Brd4 knockout reduces T cell reactivation and EAE pathology by impairing microglia-T cell interactions and neuroinflammation.
bioRxiv · Sep 13, 2024 · PreprintNeuroscience