Keiko Ozato

This study identifies HIRA as an epigenomic regulator of adipose tissue function, showing it promotes adiponectin and lipid metabolism gene expression by facilitating RNA polymerase II pause release.

This study identifies IRF8 as a B cell-intrinsic regulator of antigen presentation that sustains CD8⁺ T cell antitumor immunity and predicts response to PD-1 blockade therapy.

This study shows that histone H3.3 is essential for proliferation of myeloid progenitor cells but largely dispensable for differentiation of bone marrow-derived macrophages.

This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.

This study shows that IRF8 deficiency in microglia causes anxiety-like behavior in female mice but not males, with redox dysregulation involved.

This study shows that microglia-specific Brd4 knockout reduces T cell reactivation and EAE pathology by impairing microglia-T cell interactions and neuroinflammation.

This study uses live-cell imaging to analyze H3.3 and H3.1 dynamics, revealing that HIRA and NSD2 regulate their turnover and mobility, with H3.3 showing faster decay and dependence on transcriptional activity.

The paper introduces a single-cell genomic method to identify alternative TSSs in mouse cells and shows it is accurate and sensitive, revealing more TSSs than previous methods.

This study generates Irf8 knock-in mice modeling the human IRF8G388S mutation, showing increased osteoclast activity and tooth root resorption while sparing immune cell development.