Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes
John Beaulaurier, Shijia Zhu, Robert Sebra, Xue-Song Zhang, Chaggai Rosenbluh, Gintaras Deikus, Nan Shen, Diana Munera, Matthew K Waldor, Martin Blaser, Andrew Chess, Eric Schadt, Gang Fang
This paper introduces a novel SMRT sequencing framework for single molecule-level detection of DNA methylation and epigenetic phasing in bacterial methylomes, revealing improved resolution and distinct epigenetic heterogeneity.
bioRxiv · Sep 17, 2014Microbiology