Use of Stem Cell-Derived Cardiomyocyte and Nasal Epithelium Models to Establish a Multi-Tissue Model Platform to Validate Repurposed Drugs Against SARS-CoV-2 Infection
Nathan Gödde, Carmel O’Brien, Elizabeth Vincan, Aditya V. Vashi, Stephanie Olliff, Bang M. Tran, Shafagh A. Waters, Sarah Goldie, Petrus Jansen van Vuren, Shane Riddell, Matthew P. Bruce, Vinti Agarwal, Eugene Athan, Kim R. Blasdell, Simran Chahal, , Seshadri S. Vasan
The paper validates repurposed drugs against SARS-CoV-2 using stem cell-derived cardiomyocyte and nasal epithelium models, confirming fluvoxamine's antiviral efficacy in combination with other drugs.
bioRxiv · May 22, 2024 · PreprintMicrobiology