Author

Matthew P. Leighton

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Louis G. SmithiD· 1 shared Miro A. AstoreiD· 1 shared Pablo G. DebenedettiiD· 1 shared Pilar CossioiD· 1 shared Robert ClarkiD· 1 shared Ryan J. SzukaloiD· 1 shared Sonya M. HansoniD· 1 shared Syma KhalidiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

Louis G. SmithORCID

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1 paper

Recent·Most cited

Cooling fast and slow: Characterising the effects of vitrification in cryo-EM and the subsequent recovery of equilibrium populations

Robert Clark, Louis G. Smith, Matthew P. Leighton, Ryan J. Szukalo, Syma Khalid, Pablo G. Debenedetti, Pilar Cossio, Miro A. Astore, Sonya M. Hanson

This study uses molecular dynamics simulations to investigate how vitrification affects the conformational ensemble of Trp-cage miniprotein and develops a thermodynamic inference framework to recover equilibrium populations from vitrified samples.

bioRxiv · Apr 24, 2026 · PreprintBiophysics