Author

Ryan J. Szukalo

Princeton UniversityORCID 0000-0002-3893-9502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Louis G. SmithiD· 1 shared Matthew P. Leighton· 1 shared Miro A. AstoreiD· 1 shared Pablo G. DebenedettiiD· 1 shared Pilar CossioiD· 1 shared Robert ClarkiD· 1 shared Sonya M. HansoniD· 1 shared Syma KhalidiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

Louis G. SmithORCID

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1 paper

Recent·Most cited

Cooling fast and slow: Characterising the effects of vitrification in cryo-EM and the subsequent recovery of equilibrium populations

Robert Clark, Louis G. Smith, Matthew P. Leighton, Ryan J. Szukalo, Syma Khalid, Pablo G. Debenedetti, Pilar Cossio, Miro A. Astore, Sonya M. Hanson

This study uses molecular dynamics simulations to investigate how vitrification affects the conformational ensemble of Trp-cage miniprotein and develops a thermodynamic inference framework to recover equilibrium populations from vitrified samples.

bioRxiv · Apr 24, 2026 · PreprintBiophysics