Author

Pablo G. Debenedetti

Princeton UniversityORCID 0000-0003-1881-1728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Louis G. SmithiD· 1 shared Matthew P. Leighton· 1 shared Miro A. AstoreiD· 1 shared Pilar CossioiD· 1 shared Robert ClarkiD· 1 shared Ryan J. SzukaloiD· 1 shared Sonya M. HansoniD· 1 shared Syma KhalidiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

Louis G. SmithORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintApr 24, 2026

Cooling fast and slow: Characterising the effects of vitrification in cryo-EM and the subsequent recovery of equilibrium populations

Robert Clark, Louis G. Smith, Matthew P. Leighton…·Sonya M. Hanson

This study uses molecular dynamics simulations to investigate how vitrification affects the conformational ensemble of Trp-cage miniprotein and develops a thermodynamic inference framework to recover equilibrium populations from vitrified samples.

2 citations

cryo-EMmechanistic / dynamical model

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