Miro A. Astore

This paper uses Bayesian ensemble reweighting on unclassified cryo-EM images to quantify RNA folding equilibria, showing agreement with bulk solution measurements.

The paper shows that dynamic RNA structures guide viral replication by enabling conformational changes necessary for protein binding and function.

This study uses molecular dynamics simulations to investigate how vitrification affects the conformational ensemble of Trp-cage miniprotein and develops a thermodynamic inference framework to recover equilibrium populations from vitrified samples.

The paper introduces cryoJAX, a cryo-EM image simulation library built on JAX for developing data analysis techniques in cryo-EM.

The paper compares methods for analyzing heterogeneity in TRPV1 cryo-EM data and finds that different methods detect different types of heterogeneity.

The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.

The paper characterizes the functional and structural defects of the R352Q CFTR mutation using patient-derived organoids and molecular dynamics simulations, showing residual function restored by potentiators but not correctors.

The paper functionally and structurally characterizes an ultra-rare CFTR mutation, showing it responds to specific potentiators and correctors, with altered lasso motif interactions affecting channel gating.