Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking
Chiara Lecchi, Alessandro Vacchini, Stefano Sainas, Marco L. Lolli, Matthew W. Luedtke, Lucia Mori, Gennaro De Libero, Silvia Balbo, Peter W. Villalta
The paper reanalyzes mass spectrometry data to identify two new compound classes that bind to MR1, using fragmentation filtering, molecular networking, and spectral database searching.
bioRxiv · May 29, 2025 · PreprintImmunology