Silvia Balbo

Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK

The paper identifies mutational signatures in cancer genomes caused by tobacco-specific nitrosamines NNN and NNK, showing their unique contribution to specific cancer types.

Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin

This study determines the structure and specificity of colibactin-DNA interstrand crosslinks using mass spectrometry and NMR, revealing how the toxin's central motif mediates sequence specificity.

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic Mutations

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats

This study examines the mutagenic effects of ethanol and acetaldehyde in rats, finding exposure-specific mutational signatures and suggesting inflammation or oxidative damage as key factors in alcohol-related cancers.

Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking

The paper reanalyzes mass spectrometry data to identify two new compound classes that bind to MR1, using fragmentation filtering, molecular networking, and spectral database searching.