Author

Peter W. Villalta

University of MinnesotaORCID 0000-0002-0067-3083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Silvia BalboiD· 3 shared Chiara LecchiiD· 2 shared Adrian Baez‐OrtegaiD· 1 shared Alessandro VacchiniiD· 1 shared Alessia StornettaiD· 1 shared Alexander E. E. Verkennis· 1 shared Bruce A. JohnsoniD· 1 shared Dylan Mckeon· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMolecular Biology

Silvia BalboORCID

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3 papers

Recent·Most cited

Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair

Yang Jiang, Moritz Jakob Przybilla, Linda V. Bakker, Foster C. Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E. E. Verkennis, Jamie T. Barnett, Adrian Baez‐Ortega, Federico Abascal, Peter W. Villalta, , Juan I. Garaycoechea

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology

The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin

Erik S. Carlson, Raphael Haslecker, Chiara Lecchi, Miguel A. Aguilar Ramos, Vyshnavi Vennelakanti, Linda Honaker, Alessia Stornetta, Estela S. Millán, Bruce A. Johnson, Heather J. Kulik, Silvia Balbo, Peter W. Villalta, Victoria M. D’Souza, Emily P. Balskus

This study determines the structure and specificity of colibactin-DNA interstrand crosslinks using mass spectrometry and NMR, revealing how the toxin's central motif mediates sequence specificity.

Science · Dec 4, 2025Peer-reviewedBiochemistry

Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking

Chiara Lecchi, Alessandro Vacchini, Stefano Sainas, Marco L. Lolli, Matthew W. Luedtke, Lucia Mori, Gennaro De Libero, Silvia Balbo, Peter W. Villalta

The paper reanalyzes mass spectrometry data to identify two new compound classes that bind to MR1, using fragmentation filtering, molecular networking, and spectral database searching.

bioRxiv · May 29, 2025 · PreprintImmunology