Transcriptomic profiling of an ex vivo model of erythropoiesis uncovers potential genes and pathways involved into the pathogenesis of sickle cell disease
Matthis Tinguely, Lennart Opitz, Dominik J. Schaer, Florence Vallelian, Markus Schmugge, Francesca Daniela Franzoso
The paper identifies differentially expressed genes and enriched pathways in SCD patient-derived erythroid cells compared to healthy controls, validated in a mouse model.
bioRxiv · Sep 26, 2023 · PreprintMolecular Biology