Lennart Opitz

The paper identifies a ciliogenesis-primed secretory cell state preferentially infected by seasonal H1N1 IAV in human airway epithelium.

This study compares multiomic profiles of human and canine soft-tissue sarcomas, revealing molecular similarities and identifying clinically relevant subgroups.

This study evaluates how PCR duplication affects RNA-seq data quality across four sequencers, finding that input amount and PCR cycles significantly impact duplication rates, with UMIs effectively reducing duplicates without losing biological information.

The paper identifies differentially expressed genes and enriched pathways in SCD patient-derived erythroid cells compared to healthy controls, validated in a mouse model.

HiDRA-seq enables high-throughput, low-cost SARS-CoV-2 testing using barcoded cDNA and NGS, allowing thousands of samples to be sequenced per run.

The paper shows that longer DNA fragments in Illumina paired-end sequencing lead to lower base quality and higher error rates in the second read.

This paper introduces NestLink, a technology for simultaneous characterization of thousands of binder molecules, identifying rare binders and overcoming limitations of traditional screening methods.