Modular engineering of embryonic-extraembryonic interactions generates advanced gastruloid morphotypes.
Natalia P. Smirnova, Sergey V. Ponomartsev, Tharvesh M. Liyakat Ali, Max Lycke, Brian K. Chung, Jonas Øgaard, Espen Melum, Thomas M. D. Combriat, Jesse V. Veenvliet, Stefan Johannes Karl Krauss
The paper describes a modular co-aggregation strategy to recreate embryonic-extraembryonic interactions in vitro, leading to more complex gastruloid morphotypes with improved lineage diversity and patterning.
bioRxiv · Nov 9, 2025 · PreprintDevelopmental Biology