Sex differences in adolescent cannabis vapor self-administration mediate enduring effects on behavioral flexibility and prefrontal microglia activation in rats
Timothy G. Freels, Sara R. Westbrook, Hayden R. Wright, Jacqulyn R. Kuyat, Erica Zamberletti, Alexandra N. Malena, Max W. Melville, Amanda M. Brown, Nicholas C. Glodosky, Darren E. Ginder, Courtney M. Klappenbach, Kristen M. Delevich, Tiziana Rubino, Ryan J. McLaughlin
This study shows that adolescent cannabis vapor use leads to lasting effects on behavior and brain structure in female rats, but not males, with higher self-administration rates in females.
bioRxiv · Jan 21, 2023 · PreprintNeuroscience