Ryan J. McLaughlin

Chronic stress facilitates behavioral engagement and alters lateral habenula activity during flexible decision making in a sex-dependent manner

This study shows chronic stress enhances task engagement in rats without impairing behavioral flexibility and reduces sex differences in lateral habenula activity during decision making.

Transgenerational effects of perinatal cannabis exposure on female reproductive parameters in mice

This study examines the transgenerational effects of perinatal cannabis exposure on female reproductive parameters in mice, finding limited impacts on reproductive function across generations.

Influence of solvent, sex, and age on pharmacokinetic and acute behavioral effects of vaporized cannabis extract in mice

This study examines age and sex differences in pharmacokinetics and acute behavioral effects of vaporized cannabis extract in mice using different solvents.

Maternal cannabis use alters excitatory inputs to corticostriatal efferent neurons in rat offspring

This study investigates how maternal cannabis use affects excitatory inputs to corticostriatal neurons in rat offspring, finding sex-specific changes in synaptic activity.

Sex differences in adolescent cannabis vapor self-administration mediate enduring effects on behavioral flexibility and prefrontal microglia activation in rats

This study shows that adolescent cannabis vapor use leads to lasting effects on behavior and brain structure in female rats, but not males, with higher self-administration rates in females.

Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites are Influenced by Route of Administration and Sex

This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.

Basolateral amygdala CB1 receptors modulate HPA axis activation and context-cocaine memory strength during reconsolidation

The paper investigates the role of BLA CB1R in cocaine-memory reconsolidation and its impact on context-induced cocaine-seeking behavior and HPA axis activation.

Maternal cannabis vapor exposure causes long-term alterations in emotional reactivity, social behavior, and behavioral flexibility in offspring.

This study shows that prenatal cannabis vapor exposure in rats leads to long-term behavioral changes in offspring, including altered emotional reactivity, social behavior, and cognitive flexibility.

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

This study shows that vaporized THC-rich cannabis extracts reinforce behavior and increase drug-seeking in rats, supporting their use as a preclinical model for cannabis research.