Large Scale Cell Painting Guided Compound Selection Reveals Activity Cliffs and Functional Relationships
Maxime Sanchez, Nicolas Bourriez, Ihab Bendidi, Ethan Cohen, Ivan Svatko, Elaine Del Nery, Hamza Tajmouati, Guillaume Bollot, Laurence Calzone, Auguste Genovesio
This paper introduces a transfer learning method for compound preselection using phenotypic profiling, revealing activity cliffs and functional relationships across 112,480 compounds.
Communications Biology · Jan 13, 2026Peer-reviewedBioinformatics