Elaine Del Nery

Static2Dynamic: Reconstructing videos of unobservable cellular, developmental, and disease processes

Static2Dynamic reconstructs unseen biological dynamics from static images, enabling simulation of cellular and developmental processes not directly observable.

Large Scale Cell Painting Guided Compound Selection Reveals Activity Cliffs and Functional Relationships

This paper introduces a transfer learning method for compound preselection using phenotypic profiling, revealing activity cliffs and functional relationships across 112,480 compounds.

Integrated multiomic profiling reveals SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities

The paper identifies pathway alterations and targetable vulnerabilities in SWI/SNF-defective cancers through multiomic profiling and drug screening.

Revealing invisible cell phenotypes with conditional generative modeling

This paper uses conditional generative models to transform cell images between conditions, revealing hidden phenotypes by removing natural cell variability.

Cell Painting transfer increases screening hit rate

The paper uses Cell Painting images to preselect compounds for drug screening, significantly increasing hit rates by reducing the number of compounds tested.

Domain-invariant features for mechanism of action prediction in a multi-cell-line drug screen

The paper predicts drug mechanism of action across multiple cell lines using domain-invariant features from multitask autoencoders.

MYO1C facilitates arrival at the Golgi apparatus through stabilization of branched actin

This study identifies MYO1C as a myosin that stabilizes branched actin at the Golgi apparatus, facilitating transport carrier arrival and preventing Golgi fragmentation.

Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection

The paper identifies molecules that inhibit CCR5 transport to the cell surface and HIV infection by targeting palmitoylation.