Auguste Genovesio

Static2Dynamic reconstructs unseen biological dynamics from static images, enabling simulation of cellular and developmental processes not directly observable.

This study uses NAD(P)H FLIM to map metabolic profiles in Drosophila mushroom bodies, revealing spatial heterogeneities and learning-induced metabolic changes.

This paper introduces a transfer learning method for compound preselection using phenotypic profiling, revealing activity cliffs and functional relationships across 112,480 compounds.

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

This paper uses conditional generative models to transform cell images between conditions, revealing hidden phenotypes by removing natural cell variability.

The paper identifies and characterizes DNA methyltransferase diversity in marine microeukaryotes, showing that loss of DNMT5a leads to reduced DNA methylation and increased transposable element activity in diatoms.

The paper uses Cell Painting images to preselect compounds for drug screening, significantly increasing hit rates by reducing the number of compounds tested.

The paper identifies two subcortical nuclei in mammals that organize fluid ingestion movements, showing their role in jaw and tongue control through stimulation and activity recordings.

This study investigates how transcriptional and translational regulations coordinate during Listeria monocytogenes infection, finding that translation inhibition specifically targets translation machinery genes.

This paper develops a high-throughput method to map DNA replication at the single-molecule level using an optical mapping system.