HIV-1 Vpr alters cellular transcription by targeting the PAF1 complex
Maximilien Biguet, Kelly M. Marno, Nidia M. M. Oliveira, Joseph M. Gibbons, Corinna Pade, Christopher E Jones, Miguel Ramos Branco, Áine McKnight
This study shows HIV-1 Vpr reduces PAF1 complex levels, causing transcriptomic changes that suppress antiviral genes, aiding HIV-1 replication.
bioRxiv · Dec 18, 2024 · PreprintMicrobiology