Miguel Ramos Branco

The paper identifies high piRNA abundance as a key feature of evolutionarily persistent piRNA-producing loci across mouse and primate species.

The paper investigates the role of IAP retrotransposons in regulating placental gene expression and transcriptional diversity in mice.

This study shows HIV-1 Vpr reduces PAF1 complex levels, causing transcriptomic changes that suppress antiviral genes, aiding HIV-1 replication.

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

This study investigates the epigenetic effects of one-carbon metabolism disruption in mouse placentas, revealing genome-wide methylation instability and potential transgenerational epigenetic mechanisms.

The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.

This study identifies endogenous retroviruses that regulate trophoblast gene expression in humans, with implications for pregnancy outcomes.

The paper develops a method to generate locus-specific chromatin profiles at transposable elements using HiChIP and PAtChER, revealing epigenetic variation in young TEs in mouse and human cells.

The paper identifies endogenous retroviruses (ERVs) as a source of oncogenic enhancers in acute myeloid leukemia (AML) and shows their role in altering gene expression and promoting cell growth.

This study shows TET2 regulates microglial inflammatory responses through NF-κB-dependent pathways and metabolic changes, suggesting it as a target for neurodegenerative diseases.

The paper evaluates the role of transposable elements as enhancers in mouse embryonic and trophoblast stem cells using bioinformatics and genetic editing, finding that only a minority significantly regulate gene expression.

This study compares WGBS library preparation methods and identifies biases in sequencing data, finding that bisulfite conversion and PCR amplification are major sources of bias.

This study shows that SETDB1 prevents TET2 from demethylating H4R3 in IAP retroelements in naive ESCs, maintaining their silencing.

The paper investigates how promoter activation states influence the 3D folding of the HoxB locus in mouse ES cells using simulations and single-cell imaging.