A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1.
Maximilien Martinez, Ostiane D’Augustin, Despoina Maria Chousianiti, Virginie Gaudon, Franck Coste, Ana Gil Quevedo, Nicolas Bigot, Catherine Chapuis, Anne Marie Di Guilmi, Jean‐François Hubert, Bertrand Castaing, Anna Campalans, Sébastien Huet
The paper demonstrates that OGG1 uses coordinated amino acids to efficiently detect 8-oxoG lesions in DNA.
Cell Reports · Jan 21, 2026Peer-reviewedGenetics