Franck Coste

A new class of inherently efficient SUMOylation substrates

This paper identifies a new class of inherently efficient SUMOylation substrates by showing that ZBTB38BTB and related BTB domains can be SUMOylated efficiently without E3 ligase involvement.

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1.

The paper demonstrates that OGG1 uses coordinated amino acids to efficiently detect 8-oxoG lesions in DNA.

Cryo-EM structure of the transcription termination factor Rho from Mycobacterium tuberculosis reveals mechanism of resistance to bicyclomycin

The paper determines the cryo-EM structure of M. tuberculosis Rho, explaining its resistance to bicyclomycin and low enzymatic activity.