Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation
Hanfeng Lin, Kristin M. Riching, May Poh Lai, Dong Lu, Ran Cheng, Xiaoli Qi, Jin Wang
This study introduces lysineless HiBiT-RR and nLucK0 tagging systems to reduce degradation artifacts in monitoring protein degradation, showing HiBiT-RR retains sensitivity and nLucK0 shows different degradation patterns than nLucWT.
ACS Medicinal Chemistry Letters · Jul 28, 2024Peer-reviewedPharmacology & Toxicology