Single-particle multi-parametric microscopy reveals structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles
Albert Kamanzi, Ariadne Tuckmantel Bido, Yao Zhang, Erik Olsén, Maya Stibbards-Lyle, Martin Jasinski, Yifei Gu, Benjamin L. Wang, Michael Venier-Karzis, Romain Berti, Michelle Jeliazkova, Cynthia Shaheen, Jerry Leung, Miffy H. Y. Cheng, Pieter R. Cullis, Sabrina R. Leslie
This study uses single-particle microscopy to analyze structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles and correlates these properties with formulation parameters.
ACS Nano · Dec 19, 2025Peer-reviewedBiophysics