Erik Olsén

This paper introduces a single-particle microscopy method to directly count mRNA copies in lipid nanoparticles, showing differences in mRNA copy number, size, and empty fraction between two formulations.

The paper introduces Nano-SMF, a nanofluidic method for size and 3-color fluorescence phenotyping of single nanoparticles, demonstrating improved accuracy over existing techniques for EV analysis.

This study uses single-particle microscopy to analyze structural, size, and payload heterogeneity in mRNA-loaded lipid nanoparticles and correlates these properties with formulation parameters.

This study develops a method to characterize individual mRNA-lipid nanoparticles using confocal fluorescence and interferometric scattering microscopy with microfluidic confinement, enabling precise measurement of size, mass, refractive index, and payload.

This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.