Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling
Sadie Graves, Martin Jasinski, Erik Olsén, Albert Kamanzi, Yao Zhang, Jerry Leung, Michael Venier-Karzis, Amin Safaeesirat, Pieter R. Cullis, Sabrina R. Leslie
This paper introduces a single-particle microscopy method to directly count mRNA copies in lipid nanoparticles, showing differences in mRNA copy number, size, and empty fraction between two formulations.
Analytical Chemistry · May 29, 2026Peer-reviewedBiophysics