The break in the cycle: Inositol pyrophosphate fluxomics disentangled via mathematical modelling
Jacques Hermes, Geun-Don Kim, Guizhen Liu, Maria Giovanna De Leo, Mayer Andreas, Henning Jacob Jessen, Timmer Jens
This study uses mathematical modeling to show that 1,5-InsP8 synthesis follows a linear pathway in yeast and human cells, challenging previous assumptions about IPP metabolism.
bioRxiv · Mar 27, 2025 · PreprintMolecular Biology