Henning Jacob Jessen

Inositol phosphates, pyrophosphates and the genes involved in their turnover in the streptophyte green alga Chara braunii

This study identifies a complex inositol phosphate network in the streptophyte alga Chara braunii, showing its structural and environmental responsiveness before land plants evolved.

The dynamic inositol phosphate network during development in Drosophila melanogaster

This study characterizes the dynamic changes in the inositol phosphate network during Drosophila melanogaster development using CE-MS and genetic perturbations, revealing stage-specific metabolic remodeling essential for metamorphosis and viability.

Reduced levels of inositol hexakisphosphate kinase (IP6K) impair life-cycle transitions and the intracellular development of Trypanosoma cruzi within human cardiomyocytes

This study shows that reducing IP6K levels in T. cruzi impairs key life-cycle transitions and intracellular development in human cardiomyocytes, suggesting IP6K as a potential drug target for Chagas disease.

Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.

The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.

Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza

The paper identifies VIH2 in Lotus japonicus as an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza by linking phosphate starvation responses to root endosymbiosis.

Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsP5-Binding Proteins in Plants

The paper identifies 4/6-PP-InsP5-binding proteins in Arabidopsis using affinity-based methods and shows FHA domain proteins interact with this isomer.

Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli

This paper develops photocaged MSN analogues that can be delivered into E. coli, photo-released, and tracked to study their metabolic effects.

Phytic Acid (InsP6) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function

The paper shows that phytic acid activates the HDAC3 epigenetic axis to maintain intestinal barrier function, with therapeutic potential in inflammatory bowel disease.

FRAPPe - a novel FRET-based biosensor to detect inorganic polyphosphates

The paper introduces FRAPPe, a FRET-based biosensor for detecting inorganic polyphosphates, which can quantify polyP levels and is useful for high-throughput screens.

Inositol hexakisphosphate Functions as a Cofactor and Modulator of ADAR1 Activity

This study shows that inositol hexakisphosphate (IP6) is an essential cofactor for ADAR1 activity, with its depletion reducing RNA editing and supplementation restoring it.

Simultaneous Capillary Electrophoresis - Mass Spectrometry profiling of (p)ppGpp and dinucleoside polyphosphates reveals oscillatory (p)ppGpp dynamics and a potential synchronisation between alarmones

This study uses CE-MS to profile (p)ppGpp and dinucleoside polyphosphates in bacteria, revealing oscillatory dynamics and potential synchronization between alarmones.

Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

The paper investigates how acidocalcisome-like vacuoles regulate cytosolic phosphate levels through polyphosphate synthesis and feedback mechanisms.

NUDIX Hydrolases Target Specific Inositol Pyrophosphates and Regulate Phosphate Homeostasis and Bacterial Pathogen Susceptibility in Arabidopsis

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

This study reveals how KIDINS220 and InsP8 regulate XPR1's phosphate export through structural mechanisms and evolutionary insights.

The wheat VIH2-3B, a functional PPIP5K controls the localization of fasciclin-like arabinogalactan protein

This study identifies TaVIH2-3B as a PPIP5K that interacts with TaFLA7, affecting its localization and expression in response to drought and grain development in wheat.

βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells

The paper identifies βA3/A1-crystallin as an epigenetic regulator of HDAC3 in RPE cells, showing it enhances HDAC3 activity through CK2 interaction and InsP6 regulation, linking it to AMD pathogenesis.

Mammalian mitochondrial polyphosphate is regulated by the 5-InsP7 synthase IP6K1

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

Pools of independently cycling inositol phosphates revealed by pulse labeling with 18O-water

The paper uses 18O-water labeling to study phosphate group dynamics in inositol phosphates across species, revealing distinct pools with different cycling behaviors.

The small membrane protein YohP induces membrane depolarization and ppGpp accumulation in Escherichia coli.

This study identifies YohP as a small membrane protein in E. coli that induces membrane depolarization and (p)ppGpp accumulation, leading to metabolic silencing under stress.

The break in the cycle: Inositol pyrophosphate fluxomics disentangled via mathematical modelling

This study uses mathematical modeling to show that 1,5-InsP8 synthesis follows a linear pathway in yeast and human cells, challenging previous assumptions about IPP metabolism.

Transport and InsP8 activation mechanisms of the human inorganic phosphate exporter XPR1

This study elucidates the transport mechanism of XPR1 and how InsP8 activation regulates its function through structural and functional analysis.

Structural Insights into Broad-Range Polyphosphate Kinase 2 II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis

This study characterizes two PPK2 enzymes, showing their broad substrate specificity and ability to selectively synthesize pyrimidine nucleoside diphosphates with high yield.

A Screening Approach Unveils an Unknown Mn2+ - dependent Endopolyphosphatase Activity in Yeast

The paper introduces a FRET-based assay to detect endopolyphosphatase activity in yeast, revealing a novel Mn2+-dependent enzyme in a quadruple mutant.

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development

This study identifies three phosphatase families involved in inositol pyrophosphate catabolism in plants, showing their roles in growth, development, and nutrient signaling.

Association of the benzoxazinoid pathway with boron homeostasis in maize

GWAS identified benzoxazinless3 in the benzoxazinoid biosynthesis pathway to play a role in boron homeostasis in maize.

PenTag, a Versatile Platform for Synthesizing Protein-Polymer Biohybrid Materials

PenTag enables specific, covalent conjugation of proteins to ligands for biohybrid material synthesis, demonstrating applications in hydrogels and computational systems.

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system

The paper profiles inositol pyrophosphates in mammalian organs, identifies IP6K2 as a key enzyme for IP7 metabolism in the enteric nervous system, and shows its role in neuronal development and function.