MHC-I downregulation is associated with immune-evasion in breast cancers with heterogeneous activation of epithelial-mesenchymal plasticity
Kimaya M. Bakhle, Andreas Stephanou, Sarthak Sahoo, Ioannis Ntekas, Kaden Priebe, Mayisa Rahman, Rishi Puri, Scott D. Butler, Peter A. Schweitzer, Shiney Chandraganti, Mohit Kumar Jolly, Iwijn De Vlaminck, Praveen Sethupathy, Anushka Dongre
The paper shows that in mixed E-qM breast tumors, qM cancer cells create immunosuppressive niches leading to MHC-I downregulation and immune evasion.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology