Structural basis of canonical TIR-NLR activation in plant innate immunity
Natsumi Maruta, Weixi Gu, Bryan Y. J. Lim, Mitchell Sorbello, Dalton H. Y. Ngu, Chacko Jobichen, Jeffrey D. Nanson, Yan Li, Jian Chen, Megan A. Outram, Maud Bernoux, Md Motiur Rahman, Thi Danh Vu, Hongyi Xu, Lei Wang, , Boštjan Kobe
The paper determines cryo-EM structures of a plant TNL NLR, revealing its activation mechanism and NAD+ recognition, which informs engineering disease-resistant crops.
bioRxiv · Feb 6, 2026 · PreprintPlant Biology