Hongyi Xu

Structural basis of canonical TIR-NLR activation in plant innate immunity

The paper determines cryo-EM structures of a plant TNL NLR, revealing its activation mechanism and NAD+ recognition, which informs engineering disease-resistant crops.

Continuous Serial Electron Diffraction for High Quality Protein Structures

This paper introduces c-SerialED, a method for high-quality protein structure determination using continuous serial electron diffraction, achieving atomic resolution with reduced radiation damage.

AutoLEI: An XDS-based Graphical User Interface for Automated Real-time and Offline Batch 3D ED/MicroED Data Processing

AutoLEI provides a GUI for automated real-time and offline batch processing of 3D ED/MicroED data, improving efficiency and reducing redundant work.

A simple pressure-assisted method for MicroED specimen preparation

This paper introduces a simple pressure-assisted method for preparing MicroED specimens, enabling control over ice thickness and handling diverse crystal samples.

Visualizing drug inhibitor binding interactions using microcrystal electron diffraction

This study uses MicroED to visualize a sulfonamide inhibitor bound to human carbonic anhydrase II at the atomic level, demonstrating its potential for drug discovery.

Solving the first novel protein structure by 3D micro-crystal electron diffraction

This paper solves the first unknown protein structure using MicroED, demonstrating its potential for discovering novel protein structures.