A conditional, myeloid-cell specific estrogen receptor α deletion reprograms the liver immune microenvironment and impedes the growth of colon carcinoma liver metastases
Orçun Haçarız, Megan Kalaw, Qin Yang, Stéphanie Perrino, Pnina Brodt
This study shows that deleting estrogen receptor α in myeloid cells reduces liver metastases by altering the immune microenvironment and increasing cytotoxic T and NK cells.
bioRxiv · Aug 31, 2026 · PreprintCancer Biology