Synapsin-caveolin-1 mitigates cognitive deficits and neurodegeneration in Alzheimer's disease mice
Shanshan Wang, Joseph S. Leem, Sonia Podvin, VIVIAN Y. H. HOOK, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Alexander M. Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, , Brian Patrick Head
This study shows that re-expressing caveolin-1 in Alzheimer's disease mice improves cognitive function and reduces neurodegeneration without affecting amyloid deposits.
bioRxiv · Jul 24, 2020 · PreprintNeuroscience