Structure of human PIEZO1 and its slow inactivating channelopathy mutants
Yuanyue Shan, Xinyi Guo, Mengmeng Zhang, Meiyu Chen, Ying Li, Mingfeng Zhang, Duanqing Pei
This study presents cryo-EM structures of human PIEZO1 and its slow-inactivating mutants, revealing structural changes linked to inactivation mechanisms and channelopathies.
bioRxiv · Jul 14, 2024Molecular Biology