Xinyi Guo

This study presents cryo-EM structures of human PIEZO1 and its slow-inactivating mutants, revealing structural changes linked to inactivation mechanisms and channelopathies.

This paper demonstrates the successful restoration of valine biosynthesis in mammalian cells by integrating synthetic pathways from E. coli, showing that ancient metabolic pathways can be reactivated in metazoans.

The paper predicts Cas13 guide RNA efficacy for transcripts in model organisms and viral RNA pathogens and provides a web tool for gRNA design.

This paper introduces CRISPR-sciATAC, a method linking genetic perturbations to chromatin accessibility in single cells, showing its effectiveness in human and mouse experiments.

The paper shows the D614G mutation in SARS-CoV-2 Spike protein increases infection efficiency in multiple human cell lines by enhancing proteolytic resistance.