Duanqing Pei

SP2 impedes the pluripotent-to-totipotent state transition in an RA-dependent manner

This study identifies SP2 as a barrier to the pluripotency-to-totipotency transition in mouse embryonic stem cells, showing its role in promoting alternative developmental programs.

In vivo multimodal lineage tracing of mammalian development by DeepTrack barcoding

The paper introduces DeepTrack, a lineage tracing model that combines cellular barcoding with single-cell multi-omics to study cell fate transitions and molecular changes during mammalian development.

Chromatin context-dependent deacetylation by the asymmetric Rpd3L

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

A Single-Cell Temporal Atlas of Mouse Nasal Embryonic Development

This study creates a single-cell RNA sequencing atlas of mouse nasal development, identifying cell clusters and subtypes, and revealing regulators of lineage specification.

A Haplotype-resolved Telomere-to-Telomere Pig Genome

This paper presents a haplotype-resolved telomere-to-telomere pig genome, revealing new protein-coding loci and enabling xenograft cell state analysis and interspecies chimerism compatibility scoring.

A Phospho-Switch for Cell Fate Control

The paper identifies a phospho-switch in SALL4 that controls cell fate by modulating BAF complex interaction in response to BMP4-DUSP9 signaling, causing developmental defects when disrupted.

Structural basis for BCL7B-mediated ncBAF-nucleosome engagement

This study resolves the structural mechanism of ncBAF-nucleosome interaction, showing BCL7B's role in chromatin remodeling and its connection to nuclear actin networks.

BioLogical: a universal analysis framework for biosystem logical dynamic

BioLogical is an R package for analyzing biosystem logical dynamics, capable of multi-valued logical analysis, order parameter calculation, and system simulation.

Role of genetic frustrations in cell reprogramming

This study investigates the role of genetic frustration in cell reprogramming by constructing a Boolean genetic network model and shows its critical role in initiating cell fate transitions.

Self-Assembled Chambered Cardiac Organoids for Modeling Cardiac Chamber Formation and Cardiotoxicity Assessment

This paper develops chambered cardiac organoids (CCOs) that model cardiac chamber formation and assess cardiotoxicity through morphological and functional responses to toxic compounds.

Structure of human PIEZO1 and its slow inactivating channelopathy mutants

This study presents cryo-EM structures of human PIEZO1 and its slow-inactivating mutants, revealing structural changes linked to inactivation mechanisms and channelopathies.

Canalization and competition: the cornerstone of genetic network's dynamic stability and evolution

This study investigates how regulatory modes in gene networks contribute to dynamic stability and evolution by analyzing their impact on system criticality.

Three-dimensional molecular architecture of mouse organogenesis

This study creates a 3D spatial transcriptome atlas of mouse embryos at embryonic day 13.5, integrating with single-cell data to reveal molecular regulation of organ development.

Verified the effectiveness of AsCpf1 system in a variety of vertebrate species

The paper shows that AsCpf1 activity varies across vertebrate species due to temperature differences, as demonstrated by in vitro experiments.

Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing

Single cell RNA sequencing identifies two reprogramming branches in mouse fibroblasts, with Dppa5a marking pluripotent cells and IFN-gamma inhibiting the transition.