Cytokines driven by caspase-1 and RIPK3 are antagonistic
Lupeng Li, Jinyi (Sammy) Guo, Ying Wang, Carolyn A. Lacey, Yaxin Liu, Jianxiang Peng, Yuming Li, Heather N. Larson, Melanie N Pratt, Bart Tummers, Douglas R. Green, Edward A. Miao
The paper shows that cytokines from caspase-1 and RIPK3 pathways antagonize each other during infection, determining immune response outcomes rather than cell death pathways alone.
bioRxiv · Jul 31, 2026 · PreprintImmunology