Sortilin inhibition treats multiple neurodegenerative lysosomal storage disorders.
Hannah G. Leppert, Joelle T. Anderson, Kaylie J. Timm, Cristina Davoli, Melissa A. Pratt, Clarissa D. Booth, Katherine A. White, Mitchell J. Rechtzigel, Brandon L. Meyerink, Tyler B. Johnson, Jon J. Brudvig, Jill M. Weimer
This study shows that sortilin inhibition with AF38469 improves lysosomal and glial pathology in multiple Batten disease models.
bioRxiv · Sep 22, 2023 · PreprintNeuroscience