Author

Melissa Rose

University of Leeds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Lynn McKeowniD· 2 shared David J. BeechiD· 1 shared Harriet J. Todd· 1 shared Karen A. ForbesiD· 1 shared Katarina T. MitevaiD· 1 shared M A Bailey· 1 shared Ramzi AjjaniD· 1 shared Ryan D. Murray· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Lynn McKeownORCID

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2 papers

Recent·Most cited

Diabetes impacts endothelial Weibel-Palade body biogenesis and VWF secretion

Harriet J. Todd, Melissa Rose, Karen A. Forbes, Thomas A J McKinnon, Ramzi Ajjan, M A Bailey, Lynn McKeown

This study shows that chronic diabetes, not hyperglycaemia alone, impairs Weibel-Palade body biogenesis and VWF secretion in endothelial cells, contributing to vascular dysfunction.

bioRxiv · May 15, 2026 · PreprintCell Biology

Two-pore channel protein 2-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking

Ryan D. Murray, Melissa Rose, Katarina T. Miteva, David J. Beech, Lynn McKeown

The paper shows that TPC2-mediated Ca2+ release regulates Rab46-dependent Weibel-Palade body trafficking, promoting Ang2 secretion in endothelial cells.

bioRxiv · Mar 3, 2025 · PreprintCell Biology