Lynn McKeown

This study shows that chronic diabetes, not hyperglycaemia alone, impairs Weibel-Palade body biogenesis and VWF secretion in endothelial cells, contributing to vascular dysfunction.

The paper shows that TPC2-mediated Ca2+ release regulates Rab46-dependent Weibel-Palade body trafficking, promoting Ang2 secretion in endothelial cells.

This study uses RNA-seq to identify gene expression changes in Efcab4b knockout mice, revealing pathways linked to NAFLD progression and liver injury.

The paper identifies three SNPs in EFCAB4B (CRACR2A) associated with increased risk of COVID-19 fatality through missense mutations affecting protein structure and function.