The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region
Franck Martin, Hayden Burdett, Melody Matelot, Chloe Ngon Baroung, Beatrice Alexander-Howden, Marcus D. Wilson, Elisa Bergamin, Raphael Pantier
This study identifies a novel N-terminal region in TET1 that binds nucleosomes, enabling chromatin association in mouse embryonic stem cells through structural and biochemical validation.
bioRxiv · Nov 2, 2026 · PreprintMolecular Biology