Beatrice Alexander-Howden

This study identifies a novel N-terminal region in TET1 that binds nucleosomes, enabling chromatin association in mouse embryonic stem cells through structural and biochemical validation.

The paper identifies a dysfunction in the SET3-like complex involving TBLR1, ANKRD11, and SETD5 as a molecular basis for neurodevelopmental disorders.

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

This study shows SALL4 binds across the genome to shape chromatin and gene expression in stem cells.

The paper identifies that C-terminal deletions in MECP2 cause Rett syndrome by reducing MeCP2 levels due to a specific reading frame shift, and shows a gene-editing strategy to correct this.

The paper identifies SALL4 as a protein that interprets DNA base composition by binding to AT-rich motifs, and shows its role in controlling cell fate through regulation of AT-rich gene expression.

The paper investigates the molecular effects of non-canonical MeCP2 mutations in neurons and mice, finding they impact known domains rather than causing new molecular mechanisms of Rett syndrome.