A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b
Fernando Isaac Guillén, Mendee A. Geist, Shao-Ying Cheng, Arwen M. Harris, Martha E. Treviño, Audrey C. Brumback, Hiroshi Nishiyama, MacKenzie Allen Howard
This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.
Journal of Neuroscience · Oct 29, 2025Peer-reviewedNeuroscience