Fernando Isaac Guillén

A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b

This study develops a novel mouse model with Purkinje cell-specific Scn1b deletion, revealing cerebellar dysfunction and associated neurological impairments without early mortality.

Complex synaptic and intrinsic interactions disrupt input/output functions in the hippocampus of Scn1b knockout mice

This study investigates how loss of SCN1B affects neuronal function in the hippocampus of Scn1b knockout mice, revealing altered intrinsic excitability, synaptic properties, and information processing.